منابع مشابه
LETTER TO THE EDITOR Hippocampal Theta Frequency and Novelty
Various studies indicate that the hippocampus plays an essential role in novelty detection. In particular, contextual/spatial changes are detected by the hippocampus, presumably by comparing incoming information with stored information (e.g., Knight, 1996). However, the exact nature and processes underlying hippocampal novelty detection remain elusive. One important mechanism that may underlie ...
متن کاملEnvironmental novelty is signaled by reduction of the hippocampal theta frequency.
The hippocampal formation (HF) plays a key role in novelty detection, but the mechanisms remain unknown. Novelty detection aids the encoding of new information into memory-a process thought to depend on the HF and to be modulated by the theta rhythm of EEG. We examined EEG recorded in the HF of rats foraging for food within a novel environment, as it became familiar over the next five days, and...
متن کاملNovelty and anxiolytic drugs dissociate two components of hippocampal theta in behaving rats.
Hippocampal processing is strongly implicated in both spatial cognition and anxiety and is temporally organized by the theta rhythm. However, there has been little attempt to understand how each type of processing relates to the other in behaving animals, despite their common substrate. In freely moving rats, there is a broadly linear relationship between hippocampal theta frequency and running...
متن کاملMultiple hypothalamic sites control the frequency of hippocampal theta rhythm.
Stimulation of a neural pathway originating in the brainstem reticular formation, with synapses in the medial hypothalamus, activates the hippocampal theta rhythm. The frequency of reticular-elicited theta is determined in the medial supramammillary nucleus (mSuM) completely in anaesthetised rats, but only partially when the animal is awake. We tested other medial hypothalamic sites for their c...
متن کاملModulation of CA3 afferent inputs by novelty and theta rhythm.
Models of hippocampal function suggest that the modulation of CA3 afferent input during theta rhythm allows for a rapid alternation between encoding and retrieval states, with each phase enhancing either extrinsic or intrinsic CA3 afferents, favoring either encoding or retrieval, respectively. Here, we show that during the initial exploration of a novel environment by rats, intrinsic CA3-CA3 sy...
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ژورنال
عنوان ژورنال: Hippocampus
سال: 2009
ISSN: 1050-9631,1098-1063
DOI: 10.1002/hipo.20541